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Author

R. Maruyama

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Open access Aug 2026

Distal-less homeobox 5 gives rise to myofibroblastic carcinoma-associated fibroblasts to promote collective breast cancer invasion

Tumor-promoting myofibroblastic carcinoma-associated fibroblasts (myCAFs) are induced by activation of transforming growth factor-β (TGF-β) signaling. However, the molecular basis of myCAF-specific transcriptional programs regulated by TGF-β signaling remains poorly understood. Using a meta-analysis of single-cell RNA-...

Yoshihiro Mezawa, Kohei Kumegawa, Katsuki Morita et al. · 0 citations
Open access Jul 2026

Colorectal cancer co-opts an epidermal wound healing program during metastasis to generate disseminated tumor cells

It is shown that CRC cells transiently adopt a wound-healing program normally used by epidermal keratinocytes during tissue repair to enable metastatic dissemination, and this state is reversible, as cells reacquire primary tumor–like characteristics upon colonization of distant organs.

M. Sakahara, Takuya Okamoto, Kohei Kumegawa et al. · 0 citations

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