Open access
Aug 2026
Ten Non-N-Terminal-Domain Inhibitors of the Hsp90 Chaperone Machine Fail to Elicit Canonical Proteome-wide Responses in Jurkat Leukemia Cells.
Heat shock protein 90's (Hsp90) roles in cancer have prompted the development of small-molecule inhibitors that target its N-terminal ATP-binding pocket. Moreover, numerous alternative Hsp90 inhibitors (AHI) have been developed to target other sites of the Hsp90 chaperone complex. Alternative Hsp90 inhibition is typica...
Sean A. Gile, Janet Rogers, M. Balch et al.
· Journal of Proteome Research · 0 citations