Author

R. McCutcheon

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Open access Aug 2026

Relapse trajectories and antipsychotic discontinuation in schizophrenia from individual participant data of five trials from the Yale Open Data Access database: a meta-analysis.

It is found that rapid relapse was not over-represented among those who discontinued treatment, which is not the pattern expected if rapid relapse following paliperidone discontinuation were commonly a pharmacological discontinuation effect.

Krisya Louie, S. Jauhar, J. Rubio et al. · Lancet psychiatry · 1 citation

Open access Sep 2026

Dopamine antagonists and dynamic symptom networks in schizophrenia.

It is suggested that effective treatment weakens maladaptive symptom coupling, offering new insights into the mechanisms of clinical improvement and potential targets for intervention.

Elizabeth A. Kenny, B. Brand, O. Ebrahimi et al. · The British journal of psych... · 0 citations

Open access Sep 2026

Striatal dopaminergic function and cortical functional connectivity in 22q11.2 deletion syndrome: an integrative multimodal 18F-DOPA PET and magnetic resonance imaging study.

Dopaminergic signalling is critical for regulating large-scale brain network dynamics and is implicated in the pathophysiology of psychotic disorders. 22q11.2 deletion syndrome (22q11DS), a high-penetrance genetic risk factor for schizophrenia, is associated with both dopaminergic alterations and disruptions in functio...

V. Mancini, M. Rogdaki, S. Jauhar et al. · Molecular Psychiatry · 0 citations