Development, Optimization, Characterization and Evaluation of Ibrutinib-Loaded Chitosan-Shelled Nanobubbles for Ultrasound-Responsive Targeted Drug Delivery
The present study focused on the development of nanosized Ibrutinib-loaded nanobubbles using a chitosan-based shell system. A 3³ Box–Behnken Design (BBD) was employed to investigate the influence of three formulation variables, namely L-α-phosphatidylcholine (A), chitosan concentration (B), and palmitic acid concentrat...