Author

R. Milne

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Open access Sep 2026

Circulating Inflammatory Markers and Mammographic Density Phenotypes: a Mendelian Randomization Analysis

Observational studies have identified associations between circulating inflammatory markers (CIMs) and mammographic density (MD) phenotypes, but whether these associations reflect causal effects remains unclear. We utilized two-sample Mendelian randomization (MR) to assess relationships between 60 CIMs and MD phenotype...

A. H. Suger, T. A. Harrison, C. Haas et al. · medRxiv · 0 citations

Open access Aug 2026

Integration of lipidomic and polygenic risk scores within contemporary clinical cardiovascular risk assessment pathways: a multi-cohort development and validation study

Summary Background Guideline-recommended clinical risk scores such as AusCVDRisk underestimate cardiovascular disease (CVD) risk in a substantial proportion of individuals who later experience events, with up to 65% initially classified as low or intermediate risk. This limitation is most consequential in the intermedi...

Aleksandar Dakic, Jing-Qin Wu, Tingting Wang et al. · EClinicalMedicine · 0 citations

Meta-analysis Open access Aug 2026

Multi-population GWAS meta-analysis identifies bladder cancer susceptibility loci and highlights genetic regulation of smoking-related risk

A multi-population meta-analysis of genome-wide association studies, including 32,470 individuals with and 1,753,462 without bladder cancer, identifies 70 independent risk loci, of which 43 are novel, and uses experimental approaches to uncover how inherited variation influences this risk in the context of smoking.

L. Prokunina-Olsson, O. Flórez-Vargas, Michael G. Levin et al. · Nature Communications · 0 citations