Promoter DNA Methylation Metrics and Gene Expression in Human CD3+ T Cells: Sensitivity to Analytical Choices
Background/Objectives: Promoter DNA methylation is conventionally summarised as a regional mean. Two alternatives have been proposed to capture information the mean discards: the concurrence ratio derived from partially methylated bisulfite reads (CAMDA) and single-CpG Shannon (β-) entropy. Benchmarks of such metrics t...