R. Ossenkoppele

The modulatory role of early-life experiences and sex on cognitive resilience in APP/PS1 mice over time

BACKGROUND Cognitive resilience to Alzheimer’s disease (AD) can be modelled in amyloid-expressing rodents through early handling (EH). This study investigated how EH and sex affect cognition and pathology over time. METHODS We assessed cognition (open field, object recognition test, Barnes maze) in 6- and 12-month-old...

Global and regional amyloid-β in explaining APOE-ε4 and sex associations with medial temporal tau: a neuropathology study

Different functional connectivity gradients reflect aging and Alzheimer's disease.

Aging and Alzheimer's disease (AD) are accompanied by alterations to large-scale communication patterns in the brain, which can be tracked in vivo using functional connectivity. The location, direction and relevance of these changes remain widely debated, although they are rarely studied in the context of whole-cortex...

Comparison of quantitative digital and semiquantitative assessments of tau pathology in relation to regional in vivo tau PET.

Quantitative digital image analysis has emerged as a powerful tool for assessing neuropathological burden. Although previous studies have compared quantitative digital and semiquantitative pathology measures, their respective relationships with regionally corresponding in vivo tau PET measures remain poorly characteriz...

A Harmonized Visual Reading Framework for Tau PET Staging in Alzheimer Disease

Key Points Question Can a harmonized visual reading framework enable reliable, tracer-agnostic staging of tau positron emission tomography (PET) pathology for clinical use? Findings In this multicenter cross-sectional study of 681 participants scanned with multiple tau PET radiotracers, a 5-class harmonized visual read...

Neuropsychological profiles and behavioural correlates in individuals exposed to repetitive head impacts: findings from the NEwTON study

No association between cognitive function and behavioural disinhibition is found in populations at risk for CTE, and longitudinal studies employing neuroimaging and biomarker data are needed to disentangle the underlying pathology in populations at risk for CTE.