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Open access Sep 2026

Mutant p53 Gain-of-Function and Immune Suppression: Mathematical Modeling of STING-TBK1-IRF3 Axis Restoration for Enhanced Cancer Therapy.

Cancer progression is frequently driven by mutations in the tumor suppressor gene TP53. These mutations cause the protein to lose its normal growth-inhibitory functions and acquire new properties that promote tumor development and immune evasion. Recent experimental studies show that mutant p53 (mutp53) suppresses the...

Salaheldin Omer, R. Ouifki, Hermane Mambili-mamboundou · 0 citations

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