Mutant p53 Gain-of-Function and Immune Suppression: Mathematical Modeling of STING-TBK1-IRF3 Axis Restoration for Enhanced Cancer Therapy.
Cancer progression is frequently driven by mutations in the tumor suppressor gene TP53. These mutations cause the protein to lose its normal growth-inhibitory functions and acquire new properties that promote tumor development and immune evasion. Recent experimental studies show that mutant p53 (mutp53) suppresses the...