Open access
Oct 2026
Convergent genetic and functional evidence implicate KCND3 in Brugada Syndrome
Background: Dysfunction of the KCND3-encoded Kv4.3 channel, which carries the transient outward potassium current (Ito), has long been suspected to contribute to the pathophysiology of Brugada Syndrome (BrS). Although recent genome-wide association studies (GWAS) have implicated KCND3, the role of rare variation in thi...
H. Liu, A. Verkerk, P. Lindenbaum et al.
· medRxiv · 0 citations