Author

R. Pingaew

3 papers indexed here

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Open access Sep 2026

Anti-proliferative and anti-inflammatory potential of 2-chloro-3-((4-hydroxyphenyl)amino)naphthalene-1,4-dione through targeting TNF-α/IL-8 and NF-κB signaling in HCT116 cancer cells: a comprehensive in silico docking and in vitro study

Findings suggest that compound 12 exerts anticancer activity through dual anti-inflammatory and pro-apoptotic mechanisms, possibly by modulating the NF-κB pathway, and may represent a promising lead candidate for further drug development against CRC.

Sakdiphong Punpai, Panupong Mahalapbutr, Panyakorn Taweechat et al. · Biochemistry and Biophysics... · 0 citations

Open access Sep 2026

Anilino-1,4-naphthoquinone derivatives exhibit antiproliferative, anti-inflammatory, and pro-apoptotic activities in LPS-stimulated SW480 colorectal cancer cells: In vitro and in silico studies.

Findings establish compound 12 as a promising lead candidate for the development of new anti-colorectal cancer agents and provide mechanistic insights into the interplay between COX-2 inhibition, inflammatory modulation, and apoptosis induction in inflammation-associated colorectal carcinogenesis.

Sakdiphong Punpai, Panupong Mahalapbutr, Panyakorn Taweechat et al. · Biomedicine & pharmacotherap... · 0 citations

Open access Aug 2026

Discovery of Bis-Thiourea Derivatives as Human DNA Topoisomerase IIα Inhibitors with Potent Anticancer Effects

DNA topoisomerase IIα (Topo IIα) is essential for maintaining genomic stability during DNA replication and mitosis and is highly expressed in cancer cells, making it a promising target for anticancer therapy. In this study, bis-thiourea derivatives were investigated for their Topo IIα inhibitory activity and anticancer...

Sahachai Sabuakham, Sarunya Kitdumrongthum, Sutita Nasoontorn et al. · ACS Omega · 0 citations