Clinical Imaging of 225Ac in a PET Scanner via Time-of-Flight Cascade γ-Ray Imaging.
Clinical imaging of the α-therapy radionuclide 225Ac and its progeny has proven challenging with SPECT because of low detection efficiency and a poor signal-to-noise ratio (SNR). We propose an alternative nuclear imaging modality that enables imaging of 225Ac in PET scanners: time-of-flight cascade γ-ray imaging (TOF-C...