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R. Rademakers

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Review Open access Oct 2026

TMEM106B risk converges on C-terminal fragment homeostasis: genetics, mechanisms and therapy

TMEM106B is a genetic modifier influencing susceptibility to multiple neurodegenerative disorders, including frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP), Alzheimer’s disease, Parkinson’s disease, and limbic-predominant age-related TDP-43 encephalopathy, as well as contributing to healthy brain...

Miranda Lastra Osua, Jolien Perneel, Cristina T. Vicente et al. · 0 citations

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