R. Rathish

Aptamer-functionalized silver nanoparticle pre-analytical enrichment integrated with loop-mediated isothermal amplification for improved detection of pathogenic Leptospira interrogans.

Early diagnosis of leptospirosis remains challenging because the low and transient leptospiraemia during the acute phase often results in bacterial DNA concentrations below the analytical detection limit of conventional molecular assays. This proof-of-concept study evaluated the feasibility of integrating aptamer-funct...