Author

R. Rockne

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Open access Oct 2026

Intranasal L-MYC Neural Stem Cells Restore Neurovascular and Neuroimmune Homeostasis After TBI via CX3CL1 Upregulation and ICAM-1 Downregulation

Traumatic brain injury (TBI) triggers persistent neuroimmune and neurovascular dysfunction that contributes to secondary brain injury and limits recovery. Here, we investigated whether a single intranasal dose of LMNSC01 could reprogram post-traumatic neuroinflammatory and neurovascular responses and whether these effe...

Brecken Enright, Jeffrey P. Cheng, V. Adhikarla et al. · bioRxiv · 0 citations

Open access Aug 2026

Extracellular Vesicles Derived from L-MYC Neural Stem Cells Mediate Neuroprotection in 3D Models of Chemotherapy- and Radiation-Induced Neurotoxicity

Background/Objectives Cancer survivors frequently experience long-term neurocognitive impairments following chemotherapy and cranial irradiation, yet experimental models that enable mechanistic investigation of therapy-induced neurotoxicity at the transcriptional level remain limited. This study aimed to develop a huma...

Lance G. A. Nunes, Isabella Vasquez, Brecken Enright et al. · bioRxiv · 0 citations

Open access Jul 2026

Resolving Immune Lineage and Cell-State Heterogeneity in Human PBMCs via Mass Spectrometry-Based Single-Cell Proteomics

This work developed an integrated experimental and computational pipeline for protein-level cell annotation and applied it to human PBMCs as an immune-cell test case, delivering an analytically benchmarked SCP workflow that resolves immune lineage and cell-state heterogeneity in human PBMCs and provides a classifier-re...

S. O'Connor, Romell B. Gletten, Ritin Sharma et al. · bioRxiv · 1 citation