Author

R. Rodriguiz

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Open access Sep 2026

Microglial dectin-1/Clec7a in an alzheimer’s disease model: a double-edged sword across the lifespan

Microglial dectin-1 exerts age-dependent effects: beneficial for amyloid pathology in mid-life but detrimental for cognition and anxiety-related behavior in later life, highlighting the need to consider age, the cell types expressing dectin-1, and dectin-1-activating ligands.

Wen-Tin Xi, R. Rodriguiz, William C. Wetsel et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

A cholinergic hub in the nucleus accumbens gates opioid-reward learning

Cell-type-specific opioid blockade in accumbal cholinergic interneurons abolishes morphine-reward learning without impairing analgesia and decouples morphine-evoked dopamine elevations from acetylcholine dips, suggesting pro-cholinergic strategies to limit early opioid reward acquisition.

S. Yousefzadeh, Hai-Dun Yan, Seung-Hwa Kwak et al. · Nature · 2 citations