Liposomal nanoparticle mediated gene modulation for the treatment of melanoma in murine models.
Melanoma is a treatment-resistant and highly aggressive form of skin cancer. The aberrant activation of the Wnt/β-catenin pathway is a key driver of proliferation, tumor progression, and metastasis in many cancers, including melanoma. The active involvement in tumor growth and immune evasion makes the Wnt/β lipoplexes-...