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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

R. Shui

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Aug 2026

Structure-guided discovery of small-molecule ICOS-ICOSL antagonists that remodel intratumoral immunity and enhance anti-PD‑1 therapy in osteosarcoma.

The inducible T‑cell co‑stimulator (ICOS)-ICOS ligand (ICOSL) axis shapes effector versus regulatory T‑cell programs in tumors, yet small‑molecule disruption of this protein-protein interaction remains underexplored. We used the ICOS-ICOSL complex to define an interfacial hotspot and applied DrugCLIP to screen approxim...

Xianwen Yan, Xuan Sun, R. Shui et al. · 0 citations

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