Author

R. Simon

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Open access Sep 2026

Integrated signatures define mutational processes in prostate cancer.

Prostate cancer follows a long and heterogeneous disease course with incompletely understood aetiology1. Here we dissect the mutational processes shaping the genomes of 959 donors from the Pan Prostate Cancer Group and assess their clinical relevance. By integrating de novo extracted single-base substitution, insertion...

A. Gruber, A. Olsen, Bárbara Hernando et al. · Nature · 1 citation

#artificial intelligence Open access Sep 2026

Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC.

Despite a decade in, immunotherapy (IO) treatment selection in non-small cell lung cancer (NSCLC) remains largely guided by subgroup analyses and imperfect programmed death ligand 1 (PD-L1) and clinical scores. To our knowledge, I3LUNG ( NCT05537922 ) is currently the largest international, real-world, multimodal, arti...

A. Prelaj, V. Mišković, Matteo Sacco et al. · Nature Medicine · 0 citations