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Author

R. Smith

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Open access Aug 2026

Age and CMV are not associated with clinical or immunological response to immune checkpoint blockade

Ageing and cytomegalovirus (CMV) infection drive major alterations to T-cell immunity. Age is also associated with an increased risk of cancers including melanoma, which is treated with T-cell modifying immune checkpoint blockade (ICB). However, the extent to which age, CMV, and treatment-induced immune changes interac...

J. M. Edwards, S. Senthi, R. Smith et al. · 0 citations
Open access Jul 2026

Human embryonic stem cell-derived dopaminergic cells for Parkinson’s disease: a phase 1/2 open-label trial

A phase 1/2 trial of an off-the-shelf stem cell-derived dopaminergic progenitor therapy demonstrated a favorable 12-month safety profile, with no graft-related adverse events, dyskinesias or tumor formation, although risks were associated with the immunosuppression regimen.

G. Paul, H. Bjartmarz, A. Kirkeby et al. · 2 citations

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