Proteomics is the large-scale study of proteins. Mass spectrometry (MS) is one of the most informative techniques for analyzing proteins. Proteomics-based MS examines biological changes in diseases. It also identifies potential biomarker candidates in early disease stages, enabling the diagnosis, prognosis, and evalu...
Haneen Alharbi, Amy Campbell, R. Unwin· Journal of Proteome Research· 0 citations
Stably, a Python package that implements stability selection with formal false positive control for DIA proteomics data, is developed and shows that the Shah and Samworth complementary pairs stability selection framework recovers more true synthetic biomarkers than the Meinshausen and Bühlmann framework at moderate eff...
Daniel Byrne, M. McNamara, R. Unwin· bioRxiv· 0 citations
Emerging evidence on urinary biomarkers for endometrial cancer detection is summarized, including somatic mutations, DNA methylation markers, proteins and peptides, vibrational spectroscopy signatures, microRNAs, metabolites and urine cytology.
Molly Dore, Jiexin Cao, Holly Baker-Rand et al.· British Journal of Cancer· 0 citations
This work illustrates an initial step toward improving protein quantification starting at the spectral library level by filtering precursors which are poor quantitative representatives of their parent proteins, which could enable development of universal tissue-specific refined spectral libraries able to improve quanti...
Bethany A. Barnes, Haneen Alharbi, R. Unwin· bioRxiv· 0 citations
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