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Open access Oct 2026

Insights into Inhibitory Effects of Lapachol against Zika Virus

The reemergence of Zika virus (ZIKV) in 2015 and its association with severe neurological manifestations highlighted the urgent need for effective antiviral therapies, which, despite extensive efforts, remain unavailable. Lapachol, a 1,4-naphthoquinone compound abundant in Brazilian plant species, seems to be a promi...

Stephanie Paola Borjas Reyes, N. Cassani, João Victor Rodrigues Dutra et al. · 0 citations
Open access Aug 2026

Pyridin-3-carbohydrazide strongly impairs Mayaro and Chikungunya virus replication in vitro

Alphaviruses, including Mayaro virus (MAYV) and Chikungunya virus (CHIKV), pose a growing public health threat, with increasing reports worldwide and no licensed antiviral treatments available. This study evaluated the antiviral activity of pyridine-3-carbohydrazide (P-3-C) against MAYV (strains BeAr and TRVL) and CHIK...

N. Contreras, N. Cassani, Mikaela dos Santos Marinho et al. · 0 citations

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