Author

Robin Veenstra

2 papers indexed here

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Open access Sep 2026

Integrative structure of norovirus NS3 suggests a role in RNA transport

Human noroviruses (HuNoVs) are the leading global cause of acute gastroenteritis, yet no vaccines or antiviral therapies are currently approved. The non-structural protein NS3 is a membrane-bound AAA+ ATPase of superfamily 3 (SF3) with multiple proposed roles in the norovirus replication cycle. However, the structure...

Meryl Haas, T. Hoeksma, J. Mills et al. · Nature Communications · 0 citations

Open access Aug 2026

Structure-based macrocyclization of α-ketoamides leads to potent inhibitors of coronaviral and enteroviral proteases

Viral proteases represent validated targets for direct-acting antivirals and the treatment of associated infections. In co-crystal structures of Mpro of SARS-CoV-2 with peptidomimetic inhibitors, we noticed a spatial proximity of sidechains filling the S1’ and S2 pockets, as well as those filling S3 and S1 pockets. To...

R. Akula, Haifa El Kilani, Alina Metzen et al. · Communications Chemistry · 0 citations