Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa‐Cell Programs
It is shown that protein kinase C (PKC) phosphorylates FOXL2 in vitro, and hypothesized that PKC‐dependent phosphorylation within the FOXL2 DNA‐recognition helix would underlie a rapid, reversible switch, weakening DNA binding, redirecting subnuclear partitioning, and rewiring protein–protein interactions, thereby resh...