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R. Veitia

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Open access Aug 2026

Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa‐Cell Programs

It is shown that protein kinase C (PKC) phosphorylates FOXL2 in vitro, and hypothesized that PKC‐dependent phosphorylation within the FOXL2 DNA‐recognition helix would underlie a rapid, reversible switch, weakening DNA binding, redirecting subnuclear partitioning, and rewiring protein–protein interactions, thereby resh...

Ludovic Mousseron, Despoina-Maria Chousianiti, Francis Poulat et al. · 0 citations
Review Open access Aug 2026

Nonlinearities and Switch‐Like Behavior in Gene Expression: From Genetics to Biochemistry and Back

Overall, this paper supports the view that HI of TFs and chromatin regulators does not rely on a single mechanism, and is a phenotypic consequence of the disruption of diverse molecular and network architectures that translate dosage perturbations into discrete biochemical and phenotypic outcomes.

R. Veitia, J. Birchler · 0 citations

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