Oct 2026
A modular platform for in cellulo target engagement profiling of chromatin reader inhibitors.
The dysregulation of acylation-reading bromodomain proteins is implicated in many diseases, making them important therapeutic targets. However, drug development is hindered by a lack of high-throughput cellular assays to measure target engagement and off-target binding in living cells. To address this gap, we developed...
Davide C. Recchia, Richard Cardoso da Silva, Mathilde Noël et al.
· Cell Chemical Biology · 0 citations