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R. Walters

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Open access Sep 2026

Incidence patterns and genetic validation of primary glaucoma subtypes among 1 million adults in China and the UK.

BACKGROUND/AIMS Primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) are distinct diseases, yet many glaucoma cases in population-based datasets lack subtype specification. We assessed incidence patterns of glaucoma subtypes in China and the UK and used genetic evidence to infer the likely subty...

Charles Li, Bai-Han Wang, R. Walters et al. · 0 citations
Open access Sep 2026

Genetic analyses of blood pressure traits in 140,000 admixed adults from Mexico City

Blood pressure (BP) is a major, heritable determinant of cardiometabolic health. Genome-wide association studies (GWAS) have identified thousands of BP-influencing genetic variants. People of admixed American (AMR) ancestry harbour variants that are rare in other populations yet remain understudied in GWAS. Here, we pe...

M. Turner, J. Berumen, S. Morris et al. · 0 citations
Open access Sep 2026

Proteome-wide genetic analyses identify ASGR1 as a potential biomarker linking smoking with ischemic heart disease

Tobacco smoking increases the risk of multiple diseases, but the biological mechanisms involved remain incompletely understood. Here we characterize smoking-related protein profiles to identify potentially causal biomarkers mediating smoking’s effects. In European-ancestry populations, genetically predicted smoking exp...

A. Tinworth, P. Yao, A. Iona et al. · 0 citations
Jul 2026

Cross-Ancestry Proteogenomic Analyses Identified New Therapeutic Insights for Ischemic Heart Disease.

A role for lipid-driven chronic inflammation in IHD etiology is supported, and treatment strategies simultaneously targeting multiple lipid and inflammation pathways should be prioritized for further research to improve drug treatment of IHD beyond statin therapy.

Mohsen Mazidi, N. Wright, A. Pozarickij et al. · 1 citation

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