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R. Whelan

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Open access Sep 2026

Cognitive-Motor Duality in Human M1 and Cerebellum

The translation of abstract cognitive intention into localised physical action is a defining feature of voluntary behaviour1,2. To achieve this, the brain must maintain a highly regulated preparatory state, yet the macroscopic architecture of this interface remains elusive. Historically, the primary motor cortex has be...

Chen Zheng, Shi-Tong Xiang, Chao Xie et al. · 0 citations
Review Open access Sep 2026

Electroencephalographic Signatures of Methylphenidate in ADHD: A Systematic Review and 10 Recommendations for Future Research.

OBJECTIVE Methylphenidate is the first-line treatment for ADHD, yet its neurocognitive mechanisms remain incompletely understood. Electroencephalography (EEG) has been used to examine methylphenidate's effects on brain function and has been proposed as a potential tool for monitoring treatment response. This systematic...

D. Quinn, Clodagh Earley, Iulia Scarlat et al. · 0 citations
Open access Aug 2026

Personality variability during development predicts alcohol use before and during the COVID-19 pandemic

Changes in personality during adolescence may shape future alcohol use, especially in times of societal crisis. The COVID-19 pandemic disrupted social norms and stress regulation, making it a natural experiment to examine how early-life personality trajectories predict later substance use. Using longitudinal data from...

Rabia Zohair, K. Janson, Sebastian Siehl et al. · 0 citations
Open access Aug 2026

Deep learning reveals a neurocomputational mechanism predicting depression risk in adolescents

Early detection and prevention of psychiatric disorders, particularly depression, remain as major global health challenges, yet reliable tools for identifying individuals before symptom onset are lacking. Here, we combine functional neuroimaging with computational modeling to identify a mechanistic biomarker of depress...

Han Lu, Xiaoqian Yan, Benjamin Becker et al. · 0 citations
Open access Jul 2026

Adversity and adolescent brain development: differential associations with grey and white matter across two longitudinal cohorts

It is demonstrated that different environments generate distinct biological associations with brain maturation, which underscores the need to consider both grey and white matter when assessing the neurodevelopmental pathways to outcomes across the lifespan.

Lea C. Michel, D. Rakesh, T. Banaschewski et al. · 0 citations

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