Author

R. Zanardi

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Oct 2026

Growth factor polygenic disposition shapes associations of childhood adversity with gray matter and clinical profiles in depression: A two-cohort imaging-genetics study.

AIM Adverse childhood experiences (ACE) are associated with greater symptom severity and treatment resistance in major depressive disorder (MDD), but their effects vary markedly across individuals. Growth factor polygenic profiles may contribute to this differential susceptibility by influencing stress responsivity, ne...

T. Cazzella, L. Fortaner-Uyà, Marco Paolini et al. · Psychiatry and Clinical Neur... · 0 citations

Open access Jul 2026

Mapping generalizable brain-based depression subtypes across clinical, cognitive, and neurotransmitter dimensions

Two distinguishable clusters emerged, with one showing widespread cortical thinning, anergy-related symptoms, childhood trauma, and diabetes comorbidity, and one showing widespread cortical thinning, anergy-related symptoms, childhood trauma, and diabetes comorbidity.

F. Colombo, L. Fortaner-Uyà, T. Cazzella et al. · medRxiv · 0 citations

Aug 2026

History of childhood trauma enhances the detrimental effects of recent stressors on brain structure and function in major depressive disorder.

Childhood trauma moderated the association between recent stress exposure and structural and functional brain measures in MDD, particularly within prefrontal regulatory regions, consistent with stress sensitization models and suggest that early adversity may contribute to heterogeneity in neural correlates of stress in...

S. Furno, Marco Paolini, C. Milano et al. · Journal of neural transmissi... · 0 citations