BACKGROUND
Acute graft-versus-host disease (aGvHD) remains a major complication after allogeneic hematopoietic cell transplantation (alloHCT). Adoptive regulatory T-cell (Treg) therapy may suppress alloreactive T-cell responses, but clinical implementation has been limited by donor-specific manufacturing, prolonged ex...
A. Tuettenberg, L. Ruhnke, J. Schlöder et al.· Transplantation and Cellular...· 0 citations
Pegtarazimod reduced aGVHD in mice by suppressing pro inflammatory neutrophil effector functions and preserving enterocyte integrity and the clinical trial data support tolerability of pegtarazimod in aGVHD patients and further studies are needed to determine efficacy.
Verena Holzmüller, Jana Gawron, Ann-Cathrin Burk et al.· Journal of Clinical Investig...· 0 citations
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