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Rachel de Barros-Telles

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Open access Sep 2026

Cellular prion protein levels modulate nigrostriatal vulnerability to α-synuclein oligomers in Parkinson’s disease

α-Synuclein oligomer (αSynO)-mediated neurodegeneration is a hallmark of Parkinson’s disease (PD) pathogenesis, yet the molecular mechanisms mediating this toxicity remain elusive. In this study, we investigated the cellular prion protein (PrPC) as a key modulator of αSynO-induced neurodegeneration using an integrative...

Flavio de Souza Júnyor, F. Leser, Sarah de Souza Albuquerque et al. · 0 citations

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