Open access
Aug 2026
DePARylation prevents DNA replication-driven PARP1 condensation
It is demonstrated that PARGi prolongs PARP1 residence at damaged chromatin in a manner mechanistically distinct from PARP-inhibitor-induced trapping, and dePARylation prevents the rapid nuclear extrusion of PARP1 upon S-phase entry.
Petar-Bogomil Kanev, Vanya Milanova, Preslava Berkova et al.
· bioRxiv · 0 citations