Rafaela Vrabie

Heterocyclic chemistry meets wound care: novel p-methyl-m-trifluoromethyl-phenyl-substituted pyrrol-2-one derivatives with antimicrobial and antibiofilm activity

Biofilm-associated infections represent a major challenge in the treatment of antimicrobial-resistant pathogens, particularly in chronic and wound-related infections where bacterial adherence and persistence reduce therapeutic efficacy. To address this issue, we report a rapid, economical, and efficient one-pot three-c...