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Author

Raffaele Graziano

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Open access Oct 2026

PNA-ligand conjugates enable site-selective and directional targeting of adjacent G-quadruplexes

G-quadruplexes (G4s) are non-canonical DNA structures enriched in gene promoters and involved in transcriptional regulation, making them attractive drug targets, albeit difficult to target individually with high specificity due to their structural similarity. In the human c-KIT promoter, three adjacent G4 motifs (c-KIT...

Raffaele Graziano, Enrico Cadoni, Simona Marzano et al. · 0 citations

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