Raghu Vamsi Kondapaneni

Targeting Extracellular Matrix Mechanobiology to Suppress Solid Tumor Progression.

Solid tumor progression is associated with several mechanical changes, including compression inside the tumor and stiffening and tension at the tumor edge and in the tumor-adjacent stroma. Mechanical remodeling of the extracellular matrix is an active driver of therapeutic resistance and metastatic potential. As such,...