Cyclic di-AMP signalling affects cell division and penicillin susceptibility in Streptococcus pneumoniae
Resistance to β-lactam antibiotics in the human pathogen Streptococcus pneumoniae is mainly attributed to the acquisition of mutated versions of pbp2x, pbp2b and pbp1a, encoding functional penicillin binding proteins with reduced affinity to β-lactams. This enables the bacterium to synthesise peptidoglycan required for...