Open access
Aug 2026
Physiological basis of contraceptive function of a GSK3α-selective inhibitor, manifested during epididymal sperm maturation
Abstract Glycogen synthase kinase 3 alpha (GSK3α) has emerged as a prospective target to develop male contraceptives. Global or testis-specific loss of GSK3α, but not GSK3β, results in male infertility. Previous studies demonstrated that the GSK3α-selective inhibitor BRD0705 induces reversible infertility in heterozygo...
A. Khamamkar, Rounak Roy, Dhanu Anneyplar Shivakumar et al.
· Molecular human reproduction · 0 citations