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Author

Rahul Mittal

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Open access Jul 2026

Structural Remodeling of TCR–HLA-DQ8 Recognition by a β-Cell Stress-Associated C19S Insulin Neoepitope in Type 1 Diabetes

Together, these findings provide a molecular framework for generating hypotheses about how C19S may reshape the HLA-DQ8-presented insulin recognition surface, with implications for future experimental studies of autoreactive CD4+ T cell recognition and antigen-specific tolerogenic strategies in T1D.

Rahul Mittal, F. Alipour, Prem P. Chapagain et al. · 0 citations
Review Open access Jul 2026

Molecular and epigenetic landscapes of immunosenescence in biological aging: A narrative review

This review synthesizes emerging molecular and epigenetic frameworks that redefine immunosenescence as a quantifiable and disease-modifiable dimension of biological aging rather than a passive consequence of chronological time, and highlights actionable biomarkers that enable precise stratification of immune biological...

Rahul Mittal, Danay Saavedra, Mannat Mittal et al. · 0 citations
Review Aug 2026

The Intersection of Immunosenescence, Cellular Senescence, and Type 1 Diabetes: Paving the Way for Future Interventions.

It is proposed that T1D may induce a state of premature immunosenescence, even in relatively young individuals, which may further exacerbate autoimmunity, creating a self-reinforcing cycle between autoimmunity and immune aging mechanisms.

D. Saavedra, Rahul Mittal, C. Blaschke et al. · 0 citations

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