Author

Rahul Sharma

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Open access Aug 2026

Sequence-dependent conformational and mechanical landscapes of double-stranded nucleic acids

The sequence-dependent mechanical landscapes of double-stranded nucleic acid (dsNA) remain largely unexplored beyond canonical dsDNA. We describe cgNA+, a coarse-grained predictive model of the mechanics of dsRNA, DNA:RNA hybrids, and epigenetically modified dsDNA, all parameterised from 1.26 milliseconds of atomistic...

Rahul Sharma, A. Patelli, R. Singh et al. · bioRxiv · 0 citations