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This review coalesces current knowledge on the abundance, mutational effects, and functional insights of lncRNAs in Drosophila testis and brain, highlighting their value as a model for deciphering conserved lncRNA biology and its implications for human reproductive health.
The rational design of H102-CP05, a 22-residue chimeric peptide that integrates the β-sheet breaker peptide H102 with the CD63-targeting anchor CP05 to enable extracellular vesicle (EV) delivery of an Aβ-inhibitory payload is reported, supporting H102-CP05 as a promising EV-displayed therapeutic candidate for AD.
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