Artemisinin-Loaded Lipid-Polymer Hybrid Nanoparticles with Amorphous Solid Dispersion/Mesoporous Silica Core for Targeted Delivery to Infected Erythrocytes in Malaria Therapy
This study aimed to develop a peptide-functionalized lipid-polymer hybrid nanoparticle (LPHN) system to enhance the solubility, stability, sustained release, and selective uptake of artemisinin in Plasmodium-infected erythrocytes. Artemisinin was first converted into an amorphous/mesoporous silica-based core...