Open access
Aug 2026
Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small Cell Lung Cancer
This study provides the first mechanistic characterization of KIF18A dependency in SCLC, identifying SAC competency as the primary determinant of response, and establishes a biologically informed framework for patient stratification and rational combination strategies.
Chiori Tabe, Rajesh Kumar, Yue Huang et al.
· Cancer Research Communicatio... · 0 citations