Introduction RELL1 (Receptor Expressed in Lymphoid Tissues-Like 1) is a member of the TNF receptor superfamily. Although the physiological ligands and mechanistic insights into cell signaling still remain to be elucidated, its over-expression is associated with poor prognosis and enhanced immune cell infiltration in ca...
Pathiyil Sajini Sekhar, Diya Sanjeev, Amal Fahma et al.· Frontiers in Bioinformatics· 0 citations
Methyl-CpG-binding domain protein 3 (MBD3) is a member of the methyl-CpG-binding domain (MBD) family, which functions as a scaffold within the nucleosome remodeling and histone deacetylase complex (NuRD). MBD3 has been studied extensively in pluripotency and gene regulation, particularly through chromatin remodeling. E...
Serine/threonine‐protein kinase 10 (STK10), an ERM protein kinase, functions as a membrane–cytoskeleton linker and regulates lymphocyte cortical rigidity, cell shape, adhesion, and migration. Despite its emerging relevance in immune regulation and cancer, the phosphoregulatory mechanisms governing STK10 remain poorly u...
Vaishnavi Gopalakrishnan, Amal Fahma, Althaf Mahin et al.· BioMed Research Internationa...· 0 citations
Serine/arginine-protein kinase 1 (SRPK1) is a central regulator of alternative splicing whose overexpression drives oncogenic reprogramming in multiple cancers. To understand the phosphorylation dynamics of SRPK1 activity, we performed a systematic integrative phosphoproteomic meta-analysis of 798 profiling and 232 dif...
Lipin-1 (LPIN1) is a nucleocytoplasmic phosphatidate phosphatase and transcriptional coregulator that plays essential roles in lipid metabolism, insulin signaling, and energy homeostasis. Although LPIN1 function is extensively regulated by phosphorylation, the biological significance of individual phosphosites remains...
Bristow Ben Joseph, Pathiyil Sajini Sekhar, Athira Perunelly Gopalakrishnan et al.· Omics· 0 citations
Unc-51-like autophagy-activating kinase 1 (ULK1), a serine/threonine kinase, is the central regulator of autophagy initiation and plays a crucial role in cellular homeostasis, metabolic adaptation, and stress responses. We performed a large-scale phosphoproteomic data analysis of ULK1 by systematically integrating and...
Furqaan Ahmed Basha, Sreeshma Ravindran Kammarambath, Leona Dcunha et al.· International Journal of Mol...· 0 citations
Background: Myocardin-related transcription factor B (MRTFB) acts as a transcriptional coactivator for serum response factor (SRF) and regulates actin cytoskeletal dynamics. Despite its biological significance, the phosphoregulatory network, upstream kinases, and interactors remain poorly understood. Methods: To explor...
Jetna John, Vaishnavi Gopalakrishnan, Suhail Subair et al.· Current Issues in Molecular...· 0 citations
Background: Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) is a serine/threonine kinase that exhibits oncogenic activity in various cancers. Despite the established role of MAP3K3 in signal transduction, its phosphosignaling landscape, including the mechanisms underlying its activation and the identification...
Findings identify SMG1 as a central phosphorylation hub integrating nonsense-mediated mRNA decay with genome maintenance pathways and provide the first systematic phosphosite-centric framework for understanding its regulation.
Apoorva Pai, Leona Dcunha, Athira Perunelly Gopalakrishnan et al.· Frontiers in Systems Biology· 0 citations
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