The human genome encodes a wide variety of protein kinases that regulate multiple cellular functions. These enzymes play a crucial role in amplifying and propagating intracellular signals during signal transduction. Dysregulation of protein kinase signaling is associated with vascular diseases, inflammatory disorders,...
Rajwinder Kaur, D. K. Lang, Ankita Sood et al.· RSC Advances· 0 citations
Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, represent chronic relapsing inflammatory disorders characterized by complex interactions among genetic, microbiome-related, immunological, and environmental factors. Although advances in biologics and small-molecule inhibitors have exp...
Priyanka Paul, Ankush Kumar, Rajwinder Kaur et al.· Current Medicinal Chemistry· 0 citations
Overall, pyridopyrimidine- and pyridopyrimidinones-based compounds continue to show great promise as potential anticancer agents and further research combining synthetic chemistry, biological studies, and computational approaches may lead to the development of more effective and safer drugs in the future.
