Rakesh Dixit

Linker and conjugation chemistry as determinants of ADC toxicity profiles

ADC toxicity reflects the interplay of target biology, payload potency, linker chemistry, conjugation method, drug-to-antibody ratio (DAR), physicochemical properties, and dosing schedule. Linkers and conjugation chemistry are active determinants of toxicity because they control when, where, and in what form the payloa...