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Open access Sep 2026

Multimodal discovery of a pathogenic B cell-dependent T cell state in multiple sclerosis.

B cell depleting therapies in multiple sclerosis (MS) have transformed disease management, yet the immunological mechanisms linking B cells to chronic compartmentalised CNS inflammation, the key pathological driver of disability accrual, remain poorly defined. Here, we leverage anti-CD20 therapy as an in vivo perturbat...

Redwan Farooq, Brian Cutler, M. Pisa et al. · 0 citations
Review Open access Aug 2026

Implementing the 2024 revision of the McDonald diagnostic criteria for multiple sclerosis in Germany: Practical considerations and consensus recommendations

Early and reliable diagnosis of multiple sclerosis (MS) is critical for initiating an appropriate disease-modifying therapy (DMT). The 2024 revisions of the McDonald diagnostic criteria incorporate novel fluid and imaging biomarkers aiming to facilitate an accurate and timely diagnosis. The aim of this point-of-view pa...

M. P. Wattjes, A. Bayas, Stefan Bittner et al. · 0 citations

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