Author

Ralph Witzgall

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Open access Sep 2026

Proteasome inhibition alleviates proteinuria in Lmx1b knock-in mice with dysfunctional LIM domains

Proteasomal inhibitors, drugs already approved for treatment of patients with multiple myeloma, warrant further studies to prevent renal failure in patients with nail-patella syndrome caused by mutations in the LIM domains, providing proof of principle for a novel therapeutic strategy.

Joshua Hermens, Lisa Lucke, O. Pieles et al. · Nature Communications · 0 citations

Open access Aug 2026

GRAF1-dependent endocytotic processes and the Golgi apparatus contribute to previously unrecognized intermediate stages of early ciliogenesis

A three-dimensional ultrastructural analysis reveals previously unrecognized intermediate stages in the formation of primary cilia and identifies the endocytotic protein GRAF1 as being essential during the early stages of ciliogenesis and for the delivery of plasma membrane-derived material to the developing ciliary me...

Kerstin N. Schmidt, Korbinian Buerger, Olga Maier et al. · Nature Communications · 0 citations