Aug 2026
Probing the Catalytic Promiscuity and Enhancing the Efficiency of CYP725A4 with a Taxadiene Substrate Mimic
A substrate mimic strategy using taxadien-2-one (taxadienone), which is selectively epoxidized by CYP725A4 at the C4=C5 double bond, suggests epoxidation as its major catalytic pathway, and provides crucial insights into CYP725A4 catalytic promiscuity.
Long-Hao Huang, Ming-Yuan Lai, Zi-Han Zhang et al.
· ACS Catalysis · 1 citation