Aug 2026
Discovery of iodo-phenanthroimidazole derivatives as potential HDAC1 inhibitors inducing mitophagy to suppress glioblastoma progression.
The data support a model in which HDAC1 inhibition is associated with mitochondrial dysfunction and mitophagy, contributing to tumor suppression, and highlights the potential of iodo-phenanthroimidazole derivatives as a novel therapeutic strategy for glioblastoma.
Xiaomei Shi, Jiangbo Liang, Zhuoyan Wu et al.
· Bioorganic chemistry (Print) · 0 citations