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Author

Raphael Gottardo

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2 papers indexed here

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Open access Sep 2026

Reprogramming engineered autologous T cells to overcome resistance in patients with Merkel cell carcinoma.

Immune checkpoint inhibitors (ICIs) have transformed Merkel cell carcinoma (MCC) outcomes, but most patients with MCC develop resistance. We identified T cell receptor (TCR)MCC1, a highly avid, HLA-A*02:01-restricted TCR targeting the Merkel cell polyomavirus (MCPyV) oncoprotein large-T antigen15-23. Seven patients wit...

Yuta Asano, Joshua R. Veatch, Cheng-Jung Sung et al. · 0 citations
Aug 2026

Baseline interferon signaling in monocytes and antibody-mediated innate activation are associated with reactogenicity to mRNA vaccines.

The local and systemic symptoms that follow vaccination, collectively referred to as reactogenicity, are common, yet the mechanisms underlying individual variability remain poorly understood. Through longitudinal immune profiling of vaccinated individuals and mechanistic studies in mice, we identified key immunological...

N. Madelon, Gustavo A. Ruiz Buendía, Paula Torres Rodriguez et al. · 0 citations

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