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Author

Raphael H. Valdivia

2 papers indexed here

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Open access Aug 2026

RNF213-dependent lytic destruction of Chlamydia-containing vacuoles activates host cell death pathways

The cytokine gamma-interferon (IFNγ) promotes antimicrobial cell-autonomous immunity by inducing hundreds of interferon-stimulated genes (ISGs). Among these ISGs is the ubiquitin E3 ligase RNF213 which protects host cells from a wide range of intracellular pathogens including the obligate intracellular bacterium Chlamy...

Mary S. Dickinson, Stephen C. Walsh, Robert J. Bastidas et al. · 0 citations
Open access Sep 2026

The Chlamydia trachomatis effector CT226 directly engages LRRFIP1 to recruit a multiprotein complex that limits inclusion size and progeny production

The molecular basis and functional consequences of CT226-mediated recruitment of the LFT complex to the inclusion membrane are established and a previously unrecognized role for this effector–host interaction at late timepoints of the C. trachomatis intracellular developmental cycle is uncovered.

C. Elwell, Amy Diallo, B. S. Sixt et al. · 0 citations

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