Raphael Luiz Lobo da Silva Souza

From metabolic intermediary to neurotransmitter: purinergic signaling in neurophysiology and vulnerability of brain circuits

It is argued that, under contemporary conditions characterized by chronic stress and extended lifespan, the purinergic signaling system may undergo a shift from predominantly acute to chronic engagement and promote maladaptive purinergic activity, contributing to its involvement in synaptic dysfunction, neuroinflammati...